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Compared with traditional meta-analysis using linear mixed effect models, MR-BRT relaxes the assumption of a log(linear) relationship between exposure and risk, incorporates between-study heterogeneity into the uncertainty of risk estimates, handles estimates reported across different exposure categories, automatically identifies and trims outliers, and systematically tests and adjusts for bias due to study designs and characteristics

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15 Despite the well-established epidemiological relationship and a significant amount of data, the basic mechanisms that link smoking and BC remain unknown

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The research also showed that vapers are 25% more likely to develop coronary artery disease compared to non-vapers

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